Skilarence (Dimethyl Fumarate) is a potent drug used in the treatment of plaque psoriasis, a disease that causes thickened, red and inflamed areas of skin with scaly patches. It is used in patients with moderate or severe disease for whom treatments applied direct to the skin do not work well enough.The active ingredient presents in Skilarence is dimethyl fumarate.
The side effects that may take place upon taking this drug include diarrhoea, bloating, belly ache, nausea.
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Skilarity is indicated in people in need of systemic therapy for the treatment of mild to serious plaque psoriasis. Skilarity is designed for use in the diagnosis and treatment of psoriasis under the direction and guidance of an experienced practitioner.
Should a specific dosage increase not be tolerated, the last tolerated dosage could be temporarily decreased.
If the effectiveness of therapy is seen before the full dosage, no additional dosage rise is expected. Following the clinically significant improvement of skin lesions, an incremental decrease in the daily dose of Skilarence to the maintenance dose needed by the person should be considered.
Dosage improvements could also be appropriate if experimental parameters have been identified with anomalies. Skilarence Observational Trials did not provide adequate numbers of people over and over 65 years of age to assess whether they were responding differently to those below 65 years of age. Dose modification in elderly persons is not required based on the pharmacology of dimethyl fumarate.
In patients with mild to moderate renal dysfunction no dosage change is required.